焦脱镁叶绿酸Α甲酯
- CAS号:6453-67-4
- 英文名:MPP A
- 中文名:焦脱镁叶绿酸Α甲酯
- CBNumber:CB7713107
- 分子式:C34H36N4O3
- 分子量:548.67
- MOL File:6453-67-4.mol
- 沸点 :937.4±65.0 °C(Predicted)
- 密度 :1.219±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :Chloroform (Slightly), Methanol (Slightly, Heated)
- 形态 :Solid
- 颜色 :Black
- 稳定性 :Light Sensitive
- WGK Germany :3
焦脱镁叶绿酸Α甲酯性质、用途与生产工艺
- 生物活性 Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。
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体外研究
Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m 2 in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells.Apoptosis Analysis
Cell Line: PC-3M cells Concentration: 2 μM Incubation Time: 12 h Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC 75 (2 μM+55.6 kJ/m 2 ). -
体内研究
Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice.
Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor Dosage: 15 mg/kg Administration: Tail vein injection and topical injection Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.
- 更新日期：2024/08/19
- 产品编号：HY-137473
- 产品名称：焦脱镁叶绿酸Α甲酯 Methyl pyropheophorbide-a
- CAS编号：6453-67-4
- 包装：5 mg
- 价格：900元
- 更新日期：2024/08/19
- 产品编号：HY-137473
- 产品名称：焦脱镁叶绿酸Α甲酯 Methyl pyropheophorbide-a
- CAS编号：6453-67-4
- 包装：10 mg
- 价格：1500元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6913
- 优势度：91
