SHU-9119
- CAS号:168482-23-3
- 英文名:SHU-9119
- 中文名:SHU-9119
- CBNumber:CB7675726
- 分子式:C54H71N15O9
- 分子量:1074.24
- MOL File:168482-23-3.mol
- 密度 :1.43±0.1 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
- 形态 :Powder
- 酸度系数(pKa) :13.00±0.70(Predicted)
- 颜色 :White to off-white
- 水溶解性 :Soluble to 0.20 mg/ml in water
- 序列 :Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)
- WGK Germany :3
SHU-9119性质、用途与生产工艺
- 生物活性 SHU 9119 是有效地人类黑皮素受体 3 和 4 (MC3/4R) 拮抗剂，同时也是 MC5R 的部分激动剂，对人类 MC3R, MC4R 和 MC5R 的 IC50 值分别为 0.23, 0.06 和 0.09 nM。
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靶点
IC50: 0.23 nM (MC3R); 0.23 nM (MC4R); 0.23 nM (MC5R)
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体内研究
Blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (−42%). In addition, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (−60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
- 更新日期：2024/11/08
- 产品编号：HY-P0227
- 产品名称：SHU-9119 SHU 9119
- CAS编号：168482-23-3
- 包装：1mg
- 价格：1100元
- 更新日期：2024/11/08
- 产品编号：HY-P0227
- 产品名称：SHU-9119 SHU 9119
- CAS编号：168482-23-3
- 包装：5mg
- 价格：4400元
- 公司名称：NEOMPS
- 联系电话：--
- 电子邮件：neo@neomps.com
- 国家：法国
- 产品数：2083
- 优势度：71
