SHU-9119
SHU-9119 性质
| 密度 | 1.43±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | H2O：20 mg/mL（18.62 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.00±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 0.20 mg/ml in water |
| 序列 | Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7) |
SHU-9119 用途与合成方法
IC50: 0.23 nM (MC3R); 0.23 nM (MC4R); 0.23 nM (MC5R)
Blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (−42%). In addition, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (−60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
SHU-9119 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-P0227 | SHU-9119 | 168482-23-3 | 1mg | 1100 |
| 2024-11-08 | HY-P0227 | SHU-9119 | 168482-23-3 | 5mg | 4400 |
