Pentagamavunon-1

生物活性体外研究体内研究 Pentagamavunon-1 试剂级价格

Pentagamavunon-1

CAS号:27060-70-4
英文名:Pentagamavunon-1
中文名:Pentagamavunon-1
CBNumber:CB76217807
分子式:C23H24O3
分子量:348.43
MOL File:27060-70-4.mol

Pentagamavunon-1化学性质

沸点 :562.1±50.0 °C(Predicted)
密度 :1.232±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO: 50 mg/mL (143.50 mM)
酸度系数(pKa) :10.12±0.40(Predicted)
形态 :Solid
颜色 :Light yellow to yellow

Pentagamavunon-1性质、用途与生产工艺

生物活性 Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。

体外研究

Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.

Cell Viability Assay.

Cell Line:	Human colon carcinoma WiDr.
Concentration:	1, 2.5, 5, 7.5, 10, 15, and 20 µM.
Incubation Time:	6, 12, 24, and 48 hours.
Result:	Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation.

Cell Cycle Analysis.

Cell Line:	WiDr cells.
Concentration:	1, 2.5, 5, and 10 µM.
Incubation Time:	24 h.
Result:	The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively.

体内研究

Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.

Animal Model:	Human cancer cells in a xenograf mouse model.
Dosage:	20mg/kg.
Administration:	P.O. every 2 days for 20 days.
Result:	Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus, PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells.