Pentagamavunon-1
中文名称:Pentagamavunon-1
英文名称:Pentagamavunon-1
CAS号:27060-70-4
分子式:C23H24O3
分子量:348.43
EINECS号:
Mol文件:27060-70-4.mol
Pentagamavunon-1 性质
| 沸点 | 562.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：50 mg/mL（143.50 mM） |
| 酸度系数(pKa) | 10.12±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
Pentagamavunon-1 用途与合成方法
Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.
Cell Viability Assay.
| Cell Line: | Human colon carcinoma WiDr. |
| Concentration: | 1, 2.5, 5, 7.5, 10, 15, and 20 µM. |
| Incubation Time: | 6, 12, 24, and 48 hours. |
| Result: | Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation. |
Cell Cycle Analysis.
| Cell Line: | WiDr cells. |
| Concentration: | 1, 2.5, 5, and 10 µM. |
| Incubation Time: | 24 h. |
| Result: | The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively. |
Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.
| Animal Model: | Human cancer cells in a xenograf mouse model. |
| Dosage: | 20mg/kg. |
| Administration: | P.O. every 2 days for 20 days. |
| Result: | Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus, PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells. |
Pentagamavunon-1 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-08-19 | HY-136477 | 5 mg | 600 | ||
| 2024-08-19 | HY-136477 | Pentagamavunon-1 | 27060-70-4 | 10mM * 1mLin DMSO | 660 |
Pentagamavunon-1供应商 更多
北京普西唐生物科技有限公司
联系电话：010-60605840 18892239720
产品介绍：
英文名称：Pentagamavunon-1
CAS：27060-70-4
纯度：98%
包装信息：5mg
上海林栎医药科技有限公司
联系电话： 13761635123
产品介绍：
英文名称：Pentagamavunon-1
CAS：27060-70-4
纯度：＞95%
包装信息：1G,5G
备注：现货
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：Pentagamavunon-1
CAS：27060-70-4
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：Pentagamavunon-1
CAS：27060-70-4
纯度：98%
包装信息：5mg
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：Pentagamavunon-1
CAS：27060-70-4
纯度：95.00%
包装信息：2mg;5mg;10mg
备注：试剂级
