生物活性 靶点 体外研究 体内研究 Orexin B, human TFA 试剂级价格
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Orexin B, human TFA

生物活性 靶点 体外研究 体内研究 Orexin B, human TFA 试剂级价格
Orexin B, human TFA,,结构式
Orexin B, human TFA
  • CAS号:
  • 英文名:Orexin B, human TFA
  • 中文名:Orexin B, human TFA
  • CBNumber:CB75419798
  • 分子式:C???H???N??O??S.C?HF?O?
  • 分子量:0
  • MOL File:Mol file
Orexin B, human TFA化学性质
  • 形态 :Solid
  • 颜色 :White to off-white

Orexin B, human TFA性质、用途与生产工艺

  • 生物活性 Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 Ki 值分别为 420 和 36 nM。
  • 靶点

    Ki: 420 nM (OX1), 36 nM (OX2).

  • 体外研究

    Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
    Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

  • 体内研究

    Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

    Animal Model: Male Wistar rats (180-200 g).
    Dosage: 3 nM and 30 nM.
    Administration: Administered in a 5 mL bolus through a catheter placed in the left lateral ventricle in early light phase.
    Result: Significantly augmented food intake.
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Orexin B, human TFA 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-P1339A
  • 产品名称：Orexin B, human TFA Orexin B, human TFA
  • CAS编号：
  • 包装：1mg
  • 价格：805元
  • 更新日期：2024/11/08
  • 产品编号：HY-P1339A
  • 产品名称：Orexin B, human TFA Orexin B, human TFA
  • CAS编号：
  • 包装：5mg
  • 价格：2030元
Orexin B, human TFA生产厂家
  • 公司名称：成都云希化工有限公司
  • 联系电话：+86-17380623303 +86-17380623303
  • 电子邮件：Caroline@youngshechem.com
  • 国家：中国
  • 产品数：4812
  • 优势度：58
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