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Orexin B, human TFA

Orexin B, human TFA

中文名称:Orexin B, human TFA
英文名称:Orexin B, human TFA
CAS号:
分子式:C???H???N??O??S.C?HF?O?
分子量:0
EINECS号:
Mol文件:Mol File
Orexin B, human TFA 结构式

Orexin B, human TFA 性质

形态 固体
颜色 白色至米白色

Orexin B, human TFA 用途与合成方法

Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂,与OX1和OX2结合的 Ki 值分别为 420 和 36 nM。

Ki: 420 nM (OX1), 36 nM (OX2).

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

Animal Model: Male Wistar rats (180-200 g).
Dosage: 3 nM and 30 nM.
Administration: Administered in a 5 mL bolus through a catheter placed in the left lateral ventricle in early light phase.
Result: Significantly augmented food intake.

Orexin B, human TFA供应商 更多

成都云希化工有限公司
联系电话:+86-17380623303 +86-17380623303
产品介绍:
中文名称:内源性激动剂H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
英文名称:Orexin B, human TFA
纯度:95%
包装信息:1G; 10G; 100G
备注:企业级
杭州固拓生物科技有限公司
联系电话:0571-88211921 13735575465
产品介绍:
中文名称:内源性激动剂H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
英文名称:Orexin B, human TFA
纯度:98% HPLC
包装信息:1mg;10mg;100mg;1g;100g
备注:研发级
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:Orexin B, human TFA
纯度:98%
包装信息:500μg;1mg;5mg
绍兴市均宇生物科技有限公司
联系电话:0571-88211921 15572296305
产品介绍:
中文名称:内源性激动剂H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
英文名称:Orexin B, human TFA
纯度:99% HPLC MS
包装信息:1mg;5mg;10mg;100mg;500mg;1kg;5kg;25kg
备注:科研级
杭州拜格医药科技有限公司
联系电话:0571-85350119 15888826472
产品介绍:
中文名称:内源性激动剂H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
英文名称:Orexin B, human TFA
纯度:98%
包装信息:10mg; 100mg; 1000mg

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