金精三羧酸
- CAS号:4431-00-9
- 英文名:AURINTRICARBOXYLIC ACID
- 中文名:金精三羧酸
- CBNumber:CB7463004
- 分子式:C22H14O9
- 分子量:422.34
- MOL File:4431-00-9.mol
- 熔点 :300 °C(lit.)
- 沸点 :458.99°C (rough estimate)
- 密度 :1.3860 (rough estimate)
- 折射率 :1.6230 (estimate)
- 储存条件 :+15C to +30C
- 溶解度 :1 M NH4OH: 10 mg/mL
- 形态 :powder
- 酸度系数(pKa) :2.20±0.20(Predicted)
- 颜色 :dark red to brown
- 水溶解性 :Insoluble in water.
- BRN :2228904
- CAS 数据库 :4431-00-9(CAS DataBase Reference)
- EPA化学物质信息 :Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy- (4431-00-9)
金精三羧酸性质、用途与生产工艺
- 生物活性 Aurintricarboxylic acid 是高效的，αβ- 亚甲基 -ATP 敏感选择性 P2X1Rs 和 P2X3Rs 变构拮抗剂，对 rP2X1R 和 rP2X3R 作用的 IC50 值分别为 8.6 nM 和 72.9 nM。Aurintricarboxylic acid 是一种有效的抗流感剂，通过直接抑制神经氨酸酶 (neuraminidase) 作用。Aurintricarboxylic acid 也是拓扑异构酶 II 和凋亡抑制剂。Aurintricarboxylic acid 是选择性的 TWEAK-Fn14 信号通路抑制剂。Aurintricarboxylic acid 也是一种胱硫醚-γ-裂解酶 (CSE) 抑制剂，其 IC50 值为 0.6 μM。Aurintricarboxylic acid 是能够调节 miRNA 功能的 miRNA 调节剂。
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靶点
Topoisomerase II
rP2X1R
8.6 nM (IC 50 )
rP2X3R
72.9 nM (IC 50 )
Apoptosis
miRNA
0.47 μM (IC 50 )
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体外研究
Aurintricarboxylic acid strongly inhibits rP2X1Rs and rP2X3Rs with IC 50 values of 8.6 nM and 72.9 nM, respectively, and more weakly inhibits P2X2/3Rs, P2X2Rs, P2X4Rs or P2X7Rs.
Aurintricarboxylic acid inhibition of ATP-induced currents is concentration dependent.
Aurintricarboxylic acid is a non-competitive antagonist of P2X3R.
Aurintricarboxylic acid can inhibit the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and vaccinia virus.
Aurintricarboxylic acid protects MDCK cells from infection with influenza A strains PR8, NY or N.
Aurintricarboxylic acid inhibits replication of influenza A and B viruses.
Aurintricarboxylic acid inhibits neuraminidase activities of influenza A and B viruses.
Aurintricarboxylic acid inhibits TWEAK-Fn14-mediated NF-κB activation.
Aurintricarboxylic acid (10 μM;0.5-2 hours) suppresses TWEAK-Fn14-mediated NF-κB, Akt, and Src phosphorylation in GBM cells.
Aurintricarboxylic acid blocks TWEAK-stimulated Rac1 activation and TRAF2 recruitment to Fn14 cytoplasmic domain in glioma cells.
Aurintricarboxylic acid represses TWEAK-stimulated glioma cell migration and invasion without causing cell cytotoxicity.
Aurintricarboxylic acid (Compound 8) cannot regulate loading of endogenous let-7 onto AGO2 inside cultured cells, whereas can inhibit RISC loading of exogenous siRNA.
Western Blot Analysis
Cell Line: T98G, A172, GBM44 glioma cells Concentration: 10 μM Incubation Time: 0.5 hour, 1 hour, 2 hours Result: Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines. - 化学性质 桔红色至棕红色粉末。熔点220-225℃（分解）。易溶于水，微溶于乙醇，不溶于丙酮。
- 用途 铝试剂的中间体。
- 生产方法 水杨酸与甲醛反应得到亚甲基二水杨酸，再将其与水杨酸、亚硝酰硫酯混合反应，得金黄三羧酸。
- 更新日期：2024/11/08
- 产品编号：A15905
- 产品名称：金精三羧酸 Aurintricarboxylic acid
- CAS编号：4431-00-9
- 包装：5g
- 价格：643元
- 更新日期：2024/11/08
- 产品编号：A15905
- 产品名称：金精三羧酸 Aurintricarboxylic acid
- CAS编号：4431-00-9
- 包装：25g
- 价格：2252元
- 公司名称：Sapphire Bioscience Pty. Ltd.
- 联系电话：--
- 电子邮件：sales@sapphirebioscience.com
- 国家：澳大利亚
- 产品数：84
- 优势度：58
