ML193
- CAS号:713121-80-3
- 英文名:ML193
- 中文名:ML193
- CBNumber:CB74199381
- 分子式:C28H25N5O4S
- 分子量:527.59
- MOL File:713121-80-3.mol
- 储存条件 :Store at -20°C
- 溶解度 :≤0.1mg/ml in ethanol;2mg/ml in DMSO;3mg/ml in dimethyl formamide
- 形态 :crystalline solid
- 颜色 :Off-white to yellow
ML193性质、用途与生产工艺
- 生物活性 ML-193 (CID 1261822) 是一种有效和选择性的 GPR55 拮抗剂，IC50 值为 221 nM。ML-193 对 GPR55 的选择性是 GPR35，CB1 和 CB2 的 27 倍以上。ML-193 可以改善帕金森氏病 (PD) 大鼠的运动和感觉运动缺陷。
-
靶点
IC50: 221 nM (GPR55)
-
体外研究
ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC 50 s of 0.22 μM and 0.12 μM, respectively.
ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC 50 of 0.2 μM in U2OS cells.
ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates.
ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation. -
体内研究
ML193 (1 and 5 µg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats.
Animal Model: Male Wistar rats (200-250 g) were induced experimental Parkinson by 6-hydroxydopamine (6-OHDA, 10 µg/rat) Dosage: 1 and 5 µg/rat Administration: Injected into the right striatum at a rate of 1 μL/min Result: Increased the time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats.
- 更新日期：2024/11/08
- 产品编号：HY-110125
- 产品名称：ML-193
- CAS编号：
- 包装：1 mg
- 价格：400元
- 更新日期：2024/11/08
- 产品编号：HY-110125
- 产品名称：ML193 ML-193
- CAS编号：713121-80-3
- 包装：5mg
- 价格：850元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
- 公司名称：Key Organics Ltd.
- 联系电话：--
- 电子邮件：info@keyorganics.net
- 国家：英国
- 产品数：6741
- 优势度：50
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