2-乙酰基吩噻嗪
- CAS号:6631-94-3
- 英文名:2-Acetylphenothiazine
- 中文名:2-乙酰基吩噻嗪
- CBNumber:CB7368424
- 分子式:C14H11NOS
- 分子量:241.31
- MOL File:6631-94-3.mol
- 熔点 :180-185 °C (lit.)
- 沸点 :455.7±34.0 °C(Predicted)
- 密度 :1.249±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Heated)
- 酸度系数(pKa) :-2.45±0.20(Predicted)
- 形态 :Dark yellow-orange powder
- 颜色 :Yellow to Dark Orange
- 最大波长(λmax) :244nm(MeOH)(lit.)
- CAS 数据库 :6631-94-3(CAS DataBase Reference)
2-乙酰基吩噻嗪性质、用途与生产工艺
- 生物活性 2-Acetylphenothiazine (ML171, 2-APT) 是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。
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靶点
Target Value NOX1
(HEK293)0.25 μM NOX3
(HEK293)3 μM NOX2
(HEK293)5 μM NOX4
(HEK293)5 μM xanthine oxidase
(HEK293)5.5 μM -
体外研究
Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50 =0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.
- 用途 医药中间体，用于解热镇痛新药消炎丙宁和乙酰嗪的制造。
- 更新日期：2024/11/08
- 产品编号：HY-12805
- 产品名称：2-乙酰基吩噻嗪 ML171
- CAS编号：6631-94-3
- 包装：100mg
- 价格：200元
- 更新日期：2024/11/08
- 产品编号：HY-12805
- 产品名称：2-乙酰基吩噻嗪 ML171
- CAS编号：6631-94-3
- 包装：10mM * 1mLin DMSO
- 价格：220元
- 公司名称：Azelis Benelux NV
- 联系电话：--
- 电子邮件：obe@azelis.com
- 国家：比利时
- 产品数：447
- 优势度：58
