TB5
- CAS号:948841-07-4
- 英文名:TB5
- 中文名:TB5
- CBNumber:CB73156590
- 分子式:C15H14BrNOS
- 分子量:336.25
- MOL File:948841-07-4.mol
- 沸点 :468.5±45.0 °C(Predicted)
- 密度 :1.440±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :4.30±0.24(Predicted)
- 颜色 :White to yellow
TB5性质、用途与生产工艺
- 生物活性 TB5是一种有效的、选择性MAO-B抑制剂,对MAO-B和MAO-A的Ki值分别为110 nM和1450 nM。
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靶点
Target Value MAO-B
()110 nM(Ki) -
体外研究
TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with K i and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
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体内研究
Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.
- 更新日期:2024/11/08
- 产品编号:HY-100975
- 产品名称:TB5
- CAS编号:
- 包装:5 mg
- 价格:500元
- 更新日期:2024/11/08
- 产品编号:HY-100975
- 产品名称:948841-07-4 TB5
- CAS编号:948841-07-4
- 包装:10mM * 1mLin DMSO
- 价格:550元
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6257
- 优势度:58