CGP 37157
- CAS号:75450-34-9
- 英文名:7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
- 中文名:CGP 37157
- CBNumber:CB7314153
- 分子式:C15H11Cl2NOS
- 分子量:324.22
- MOL File:75450-34-9.mol
- 沸点 :479.8±45.0 °C(Predicted)
- 密度 :1.384±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: ≥20mg/mL
- 酸度系数(pKa) :12.20±0.40(Predicted)
- 形态 :White solid
- 颜色 :white
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months.
CGP 37157性质、用途与生产工艺
- 生物活性 CGP37157 是一种 Na+/Ca2+ exchanger 抑制剂，可抑制豚鼠心脏线粒体 Na+ 诱导的 Ca2+ 的释放，IC50 值为 0.8 μM。
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靶点
IC50: 0.8 μM (Na + /Ca 2+ exchanger)
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体外研究
CGP37157 (Compound XVI) is a potent, selective inhibitor of Na + /Ca 2+ exchanger, inhibiting the Na + -induced Ca 2+ -release from guinea-pig heart mitochondria, with an IC 50 of 0.8 μM. CGP37157 (10 μM) shows inhibitory effect on mitochondrial Na + /Ca 2+ exchanger in cortical neurons, modulates intracellular Ca 2+ levels via suppresssing voltage-gated calcium channels, and reduces NMDA-induced cytosolic and mitochondrial Ca 2+ overloads. CGP37157 (10 μM) also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons. CGP37157 (10 μM) in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. Moreover, CGP37157 has no inhibitory effect on salinomycin tumor toxicity.
- 更新日期：2024/11/08
- 产品编号：HY-15754
- 产品名称：CGP37157
- CAS编号：
- 包装：1 mg
- 价格：250元
- 更新日期：2024/11/08
- 产品编号：HY-15754
- 产品名称：CGP 37157 CGP37157
- CAS编号：75450-34-9
- 包装：5mg
- 价格：500元
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
- 公司名称：BIOTREND Chemicals AG
- 联系电话：--
- 电子邮件：info@biotrend.ch
- 国家：德国
- 产品数：1250
- 优势度：62
