ChemicalBook CAS数据库列表 934369-14-9
934369-14-9
- CAS号:934369-14-9
- 英文名:TY-52156
- 中文名:934369-14-9
- CBNumber:CB73122351
- 分子式:C18H19Cl2N3O
- 分子量:364.27
- MOL File:934369-14-9.mol
934369-14-9化学性质
- 熔点 :90-91 °C
- 沸点 :62-69 °C(Press: 20 Torr)
- 密度 :1.22±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C(protect from light)
- 溶解度 :≥92.8 mg/mL in DMSO; ≥94.6 mg/mL in EtOH; insoluble in H2O
- 形态 :crystalline solid
- 酸度系数(pKa) :0.99±0.50(Predicted)
- 颜色 :Light yellow to yellow
934369-14-9性质、用途与生产工艺
- 生物活性 TY-52156 是一种有效、选择性的 S1P3 受体拮抗剂,Ki 值为 110 nM。
-
靶点
Ki: 110 nM (S1P 3 )
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体外研究
TY-52156 inhibits the S1P 3 receptor-dependent increase in [Ca 2+ ] i .
TY-52156 shows submicromolar potency and a high degree of selectivity for S1P 3 receptor.
TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.
Western Blot Analysis
Cell Line: Chinese hamster ovary K1 cells Concentration: 10 μM Incubation Time: 10 min Result: Inhibited S1P-induced p44/p42 MAPK phosphorylation. -
体内研究
TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P 3 receptor-induced bradycardia after oral administration in vivo.
Animal Model: Male SD rats (290–340 g) Dosage: 10 mg/kg, 30 mg/kg Administration: Oral administration Result: Inhibited S1P 3 receptor-induced bradycardia after oral administration in vivo.
934369-14-9上下游产品信息
上游原料
下游产品
934369-14-9 试剂级价格
- 更新日期:2024/08/19
- 产品编号:HY-19736
- 产品名称:934369-14-9 TY-52156
- CAS编号:934369-14-9
- 包装:5mg
- 价格:700元
- 更新日期:2024/08/19
- 产品编号:HY-19736
- 产品名称:934369-14-9 TY-52156
- CAS编号:934369-14-9
- 包装:10mM * 1mLin DMSO
- 价格:770元
934369-14-9生产厂家
- 公司名称:TOCRIS-US
- 联系电话:--
- 电子邮件:customerservice@tocris.co.uk
- 国家:英国
- 产品数:5729
- 优势度:77