尿石素C
- CAS号:165393-06-6
- 英文名:Urolithin C
- 中文名:尿石素C
- CBNumber:CB73051475
- 分子式:C13H8O5
- 分子量:244.2
- MOL File:165393-06-6.mol
- 熔点 :>300°C
- 沸点 :605.4±55.0 °C(Predicted)
- 密度 :1.640±0.06 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Room Temperature
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Heated)
- 酸度系数(pKa) :7.51±0.20(Predicted)
- 形态 :Solid
- 颜色 :Off-White to Pale Brown
- 稳定性 :Hygroscopic
- LogP :1.615 (est)
尿石素C性质、用途与生产工艺
- 生物活性 Urolithin C， 是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌 (insulin secretion) 的葡萄糖依赖性激活剂。Urolithin C 是一种 L 型 Ca2+ 通道开放剂，可增强 Ca2+ 的流入。Urolithin C 通过线粒体介导的途径诱导细胞凋亡 (apoptosis)，并刺激活性氧 (ROS) 的形成。
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靶点
Insulin secretion
L-type Ca 2+ channel
Reactive oxygen species (ROS)
Apoptosis -
体外研究
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells.
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis.
Urolithin C treatment induces apoptosis and S phase cell cycle arrest.Western Blot Analysis
Cell Line: INS-1 cells Concentration: 20 μM, 100 μM Incubation Time: 1 hour Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation. -
体内研究
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.
- 更新日期：2024/11/08
- 产品编号：HY-135897
- 产品名称：Urolithin C
- CAS编号：
- 包装：5 mg
- 价格：620元
- 更新日期：2024/11/08
- 产品编号：HY-135897
- 产品名称：尿石素C Urolithin C
- CAS编号：165393-06-6
- 包装：10mM * 1mLin DMSO
- 价格：680元
- 公司名称：R&D Scientific Inc.
- 联系电话：+1-2266000236
- 电子邮件：sales@rdscientific.com
- 国家：加拿大
- 产品数：1627
- 优势度：58
- 人尿皮质素 ILE-VAL-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-GLN-ILE-LEU-LEU-GLU-GLN-ALA-ARG-ALA-ARG-ALA-ALA-ARG-GLU-GLN-ALA-THR-THR-ASN-ALA-ARG-ILE-LEU-ALA-ARG-VAL-GLY-HIS-CYS-NH2 ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL 硬骨鱼紧张肽 UROTENSIN II Urotensin II (114-124), human TFA UROTENSIN II (HUMAN) 尿石素M6 3-methoxy-6H-benzo[c]chromen-6-one 尿石素A 3-羟基-6H-苯并[C]苯并吡喃-6-酮 尿石素D 尿石素M7 尿石素M5
