ChemicalBook CAS数据库列表 GYKI 47261 dihydrochloride
GYKI 47261 dihydrochloride
- CAS号:1217049-32-5
- 英文名:GYKI 47261 dihydrochloride
- 中文名:
- CBNumber:CB73037299
- 分子式:C18H17Cl3N4
- 分子量:395.71338
- MOL File:1217049-32-5.mol
GYKI 47261 dihydrochloride化学性质
- 溶解度 :Soluble to 100 mM in DMSO
- 形态 :Powder
GYKI 47261 dihydrochloride性质、用途与生产工艺
- 生物活性 GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂，IC50为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。
-
体内研究
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.Animal Model: Male C57 black mice, weighing 23-30 g Dosage: 20 mg/kg Administration: I.p. Result: Reversed the MPTP-induced decrease in striatal concentrations.
GYKI 47261 dihydrochloride上下游产品信息
上游原料
下游产品
GYKI 47261 dihydrochloride生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5729
- 优势度：77
