GYKI-47261 DIHYDROCHLORIDE
英文名称:GYKI 47261 dihydrochloride
CAS号:1217049-32-5
分子式:C18H17Cl3N4
分子量:395.71338
EINECS号:
Mol文件:1217049-32-5.mol
GYKI-47261 DIHYDROCHLORIDE 用途与合成方法
GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂,IC50为 2.5 μM,具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.
Animal Model: | Male C57 black mice, weighing 23-30 g |
Dosage: | 20 mg/kg |
Administration: | I.p. |
Result: | Reversed the MPTP-induced decrease in striatal concentrations. |
GYKI-47261 DIHYDROCHLORIDE供应商 更多
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:GYKI-47261 dihydrochloride
CAS:1217049-32-5
包装信息:5mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:GYKI-47261 dihydrochloride
英文名称:GYKI-47261 dihydrochloride
CAS:1217049-32-5
包装信息:25mg/RMB 10600
南通全益生物科技有限公司
联系电话:0513-66337626 18051384581
产品介绍:
英文名称:GYKI-47261 dihydrochloride
CAS:1217049-32-5
纯度:98%+ HPLC
包装信息:10mg,500mg,1g,2g,5g,10g,more