MIT 9952-53

BLT-1 has IC ₅₀ s of 60 and 110 nM for cellular DiI-HDL and [ ³ H]CE-HDL uptake in ldlA[mSR-BI] cells.
BLT-1 has an IC ₅₀ of 0.96 μM for the HCV entry in Huh 7.5.1 cells.
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells.
BLT-1 can inhibit SR-BI-dependent selective uptake of [ ³ H]CE from [ ³ H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC ₅₀ =0.057 µM) and liposomes (IC ₅₀ =0.098 µM) .