1281870-42-5
- CAS号:1281870-42-5
- 英文名:Rhosin (hydrochloride)
- 中文名:1281870-42-5
- CBNumber:CB72735536
- 分子式:C20H19ClN6O
- 分子量:394.86
- MOL File:1281870-42-5.mol
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol
- 形态 :A solid
- 颜色 :Light yellow to yellow
1281870-42-5性质、用途与生产工艺
- 生物活性 Rhosin (G04) hydrochloride (HCl) 是RhoA亚家族 Rho GTPases 的强效特异性抑制剂，Kd值约为0.4 uM。Rhosin hydrochloride 可诱导细胞凋亡。
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靶点
Target Value Rho
(Cell-free assay)0.4 μM(Kd) -
体外研究
Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC 50 ~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.
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体内研究
Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
Rhosin (30 µM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.Animal Model: D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background Dosage: 40 mg/kg Administration: I.p. Result: Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors.
- 更新日期：2024/11/08
- 产品编号：HY-12646
- 产品名称：Rhosin hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：1600元
- 更新日期：2024/11/08
- 产品编号：HY-12646
- 产品名称：1281870-42-5 Rhosin hydrochloride
- CAS编号：1281870-42-5
- 包装：2mg
- 价格：2330元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
