基本属性 生物活性靶点体外研究体内研究 用途与合成方法 1281870-42-5 价格(试剂级) 供应商 供应信息

1281870-42-5

1281870-42-5

中文名称:1281870-42-5
英文名称:Rhosin (hydrochloride)
CAS号:1281870-42-5
分子式:C20H19ClN6O
分子量:394.86
EINECS号:
Mol文件:1281870-42-5.mol
1281870-42-5 结构式

1281870-42-5 性质

储存条件 Store at -20°C
溶解度 DMF:10mg/mL; DMSO:5mg/mL;乙醇:5mg/mL; PBS (pH 7.2):不溶
形态 固体
颜色 浅黄至黄色

1281870-42-5 用途与合成方法

Rhosin (G04) hydrochloride (HCl) 是RhoA亚家族 Rho GTPases 的强效特异性抑制剂,Kd值约为0.4 uM。Rhosin hydrochloride 可诱导细胞凋亡。
TargetValue
Rho
(Cell-free assay)
0.4 μM(Kd)

Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC 50 ~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.

Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
Rhosin (30 µM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.

Animal Model: D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background
Dosage: 40 mg/kg
Administration: I.p.
Result: Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors.

1281870-42-5 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-12646 1 mg 1600
2024-11-08 HY-12646 1281870-42-5 1281870-42-5 2mg 2330

1281870-42-5供应商 更多

ChemeGen 中国
现货
联系电话: 18818260767
产品介绍:
英文名称:Rhosin hydrochloride
CAS:1281870-42-5
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
库存量:10g
现货日期:2024/11/15 18:20:31
上海喀露蓝科技有限公司
联系电话:18149758185 18149758185
产品介绍:
英文名称:Rhosin hydrochloride
CAS:1281870-42-5
纯度:98%
包装信息:1g,10g,100g,1kg
四川省维克奇生物科技有限公司
联系电话:028-81700200 18116577057
产品介绍:
英文名称:Rhosin hydrochloride
CAS:1281870-42-5
纯度:HPLC≥98%
包装信息:20mg/10
上海楼岚生物科技有限公司
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:Rhosin hcl
CAS:1281870-42-5
纯度:98% HPLC
包装信息:5mg,10mg,50mg,100mg,1g,5g
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:Rhosin (hydrochloride)
CAS:1281870-42-5
纯度:98.00%
包装信息:1mg;2mg;5mg
备注:试剂级

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