ChemicalBook CAS数据库列表 UNC-926
UNC-926
- CAS号:1184136-10-4
- 英文名:UNC-926 Hydochloride
- 中文名:UNC-926
- CBNumber:CB72652653
- 分子式:C16H21BrN2O
- 分子量:337.25
- MOL File:1184136-10-4.mol
UNC-926化学性质
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble2mg/mL, clear (warmed)
- 形态 :powder
- 颜色 :white to light brown
安全信息
- WGK Germany :3
UNC-926性质、用途与生产工艺
- 生物活性 UNC926 是一种 methyl-lysine (Kme) reader domain 抑制剂，可特异性抑制 L3MBTL1，其 IC50 为 3.9 μM。
-
靶点
Target Value L3MBTL1
()3.9 μM(Kd) -
体外研究
UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC 50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1. -
用途
UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull down assay.
UNC-926上下游产品信息
上游原料
下游产品
UNC-926 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-16510
- 产品名称：UNC926
- CAS编号：
- 包装：1 mg
- 价格：236元
- 更新日期：2024/11/08
- 产品编号：HY-16510
- 产品名称：UNC-926 UNC926
- CAS编号：1184136-10-4
- 包装：5mg
- 价格：590元
UNC-926生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
1184136-10-4, UNC-926相关搜索:
- UNC0321 UNC3230 UNC2881 UNC2541 1,4-伸苯基双(1,4'-二哌啶-1'-基甲酮) UNC 0224 UNC3866 UNC0379 UNC669 反式-4-[[2-(丁基氨基)-5-[5-(4-吗啉基甲基)-2-吡啶基]-4-嘧啶基]氨基]环己醇 UNC1215 CS-2399 N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺 NUC-7738;NUC 7738;NUC7738 反式-4-[2-(丁基氨基)-5-[4-[(4-甲基-1-哌嗪基)甲基]苯基]-7H-吡咯并[2,3-D]嘧啶-7-基]-环己醇 UNC0638 2-(4,4-二氟-1-哌啶基)-6-甲氧基-N-[1-异丙基-4-哌啶基]-7-[3-(1-吡咯烷基)丙氧基]-4-喹唑啉胺 UNC 0631
