ChemicalBook CAS数据库列表 AT-56
AT-56
- CAS号:162640-98-4
- 英文名:AT-56
- 中文名:AT-56
- CBNumber:CB72518821
- 分子式:C25H27N5
- 分子量:397.52
- MOL File:162640-98-4.mol
AT-56化学性质
- 沸点 :620.4±65.0 °C(Predicted)
- 密度 :1.216±0.06 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO: soluble10mg/mL, clear
- 酸度系数(pKa) :4.99±0.10(Predicted)
- 形态 :powder
- 颜色 :white to beige
- InChIKey :LQNGMDUIRLSESZ-UHFFFAOYSA-N
- SMILES :N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1
安全信息
- WGK Germany :3
AT-56性质、用途与生产工艺
- 生物活性 AT-56 是一种口服活性的 lipocalin-type prostaglandin (PG) D synthase (L-PGDS) 的选择性抑制剂，对应的Ki值和IC50值分别为75 μM和95 μM。
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靶点
Target Value L-PGDS
(Cell-free assay)75 μM(Ki) L-PGDS
(Cell-free assay)95 μM -
体外研究
AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD 2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC 50 of about 3 μM.
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体内研究
AT-56 ( 1-30 mg/kg; p.o.) suppresses the PGD 2 production in the stab-wounded brain.
AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.
AT-56 (10 mg/kg; p.o.) exhibits C max (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%).Animal Model: H-PGDS KO mice (14-16weeks, 25-30 g, C57BL/6 strain) with a stab wound brain injury Dosage: 0, 1, 3, 10, 30 mg/kg Administration: P.o. 1 h before the stab wound injury Result: Inhibited the L-PGDS reaction in the brain.
Decreased the total amount of PGD 2 in the brain to 40% with 30 mg/kg AT-56.Animal Model: Human L-PGDS-overexpressing TG mice (males, 14-16 weeks, 25-30 g) Dosage: 0, 1, 10 mg/kg Administration: P.o. 1 h before and 24 h after the antigen exposure Result: Prevented the eosinophil infiltration by inhibiting transgened human L-PGDS. Animal Model: Male C57BL/6 mice (7 weeks, 22-26 g) Dosage: 10 mg/kg for p.o. and 2 mg/kg for i.v. (Pharmacokinetic Analysis) Administration: P.o. and i.v. administration Result: Oral bioavailability (82%); C max (2.15 μg/ml); T 1/2 (1.71 h, p.o.); T 1/2 (2.35 h, i.v.).
AT-56上下游产品信息
上游原料
下游产品
AT-56 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-13988
- 产品名称：AT-56
- CAS编号：
- 包装：1 mg
- 价格：380元
- 更新日期：2024/11/08
- 产品编号：HY-13988
- 产品名称：AT-56 AT-56
- CAS编号：162640-98-4
- 包装：5mg
- 价格：950元
AT-56生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
