硫酸奥西那林

生物活性靶点体外研究体内研究硫酸奥西那林试剂级价格

硫酸奥西那林

CAS号:5874-97-5
英文名:Orciprenaline sulfate
中文名:硫酸奥西那林
CBNumber:CB7226328
分子式:C22H36N2O10S
分子量:520.59
MOL File:5874-97-5.mol

硫酸奥西那林化学性质

熔点 :202-203°
储存条件 :2-8°C
溶解度 :Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
形态 :Solid
颜色 :White to Off-White
稳定性 :Hygroscopic

安全信息

危险品标志 :Xn
危险类别码 :20
安全说明 :36
WGK Germany :2
RTECS号 :DO2275000
海关编码 :2922504500
毒性 :LD50 in rats (mg/kg): 42 orally (Goldenthal)

硫酸奥西那林性质、用途与生产工艺

生物活性 Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药，是 β2-肾上腺素能受体 (β2AR) 激动剂，其 IC50 为 68 nM。Metaproterenol hemisulfate 还具有抗炎活性。
靶点

IC50: 68 nM (β2-adrenergic receptor)

体外研究

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.

Western Blot Analysis

Cell Line:	THP-1 cells and bone marrow macrophages
Concentration:	10 μM
Incubation Time:	74 hours
Result:	Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR

Cell Line:	THP-1 cells and bone marrow macrophages
Concentration:	10 μM
Incubation Time:	74 hours
Result:	Led to downregulation of NF-κB.

体内研究

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.