硫酸奥西那林
- CAS号:5874-97-5
- 英文名:Orciprenaline sulfate
- 中文名:硫酸奥西那林
- CBNumber:CB7226328
- 分子式:C22H36N2O10S
- 分子量:520.59
- MOL File:5874-97-5.mol
- 熔点 :202-203°
- 储存条件 :2-8°C
- 溶解度 :Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- 形态 :Solid
- 颜色 :White to Off-White
- 稳定性 :Hygroscopic
硫酸奥西那林性质、用途与生产工艺
- 生物活性 Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药，是 β2-肾上腺素能受体 (β2AR) 激动剂，其 IC50 为 68 nM。Metaproterenol hemisulfate 还具有抗炎活性。
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靶点
IC50: 68 nM (β2-adrenergic receptor)
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体外研究
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.Western Blot Analysis
Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Enhanced β-arrestin2 and its interaction with IκBα. RT-PCR
Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Led to downregulation of NF-κB. -
体内研究
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
- 更新日期：2024/11/08
- 产品编号：HY-B1276
- 产品名称：硫酸奥西那林 Metaproterenol hemisulfate
- CAS编号：5874-97-5
- 包装：50mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-B1276
- 产品名称：硫酸奥西那林 Metaproterenol hemisulfate
- CAS编号：5874-97-5
- 包装：10mM * 1mLin DMSO
- 价格：550元
- 公司名称：SIGMA
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- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
- 公司名称：BIOSYNTH
- 联系电话：--
- 电子邮件：welcome@biosynth.ch
- 国家：瑞士
- 产品数：3324
- 优势度：72
