三氯卡班

Bacterial

Triclocarban (300 nM) potentiates the cytotoxicity of 300 µM H ₂ O ₂ in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H ₂ O ₂ , resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.

Triclocarban is absorbed significantly from soap used during showering in human subjects and that its C _max in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.