二苯甲酰基甲烷
- CAS号:120-46-7
- 英文名:Dibenzoylmethane
- 中文名:二苯甲酰基甲烷
- CBNumber:CB7175433
- 分子式:C15H12O2
- 分子量:224.25
- MOL File:120-46-7.mol
- 熔点 :77-79 °C(lit.)
- 沸点 :219-221 °C18 mm Hg(lit.)
- 密度 :0.800 g/cm3
- 蒸气压 :0.01Pa at 20℃
- 折射率 :1.6600 (estimate)
- 闪点 :219-221°C/18mm
- 储存条件 :Store below +30°C.
- 溶解度 :Chloroform (Slightly), Methanol (Slightly, Sonicated)
- 酸度系数(pKa) :8.95±0.10(Predicted)
- 形态 :Crystals
- 颜色 :Light yellow to yellow
- 水溶解性 :It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.
- Merck :14,3009
- BRN :514910
- 稳定性 :Stable. Incompatible with strong oxidizing agents.
- InChIKey :NZZIMKJIVMHWJC-UHFFFAOYSA-N
- LogP :4.59 at 25℃
- CAS 数据库 :120-46-7(CAS DataBase Reference)
- NIST化学物质信息 :1,3-Propanedione, 1,3-diphenyl-(120-46-7)
- EPA化学物质信息 :1,3-Propanedione, 1,3-diphenyl- (120-46-7)
二苯甲酰基甲烷 MSDS
Dibenzoylmethane
二苯甲酰基甲烷性质、用途与生产工艺
- 生物活性 Dibenzoylmethane 是甘草中的次要成分，可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物，会引起 Keap1 解离和 Nrf2 的核易位。
-
体外研究
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity.
-
体内研究
Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.
- 化学性质 无色斜方形片状结晶。熔点81℃，沸点219℃（2.4kPa）。易溶于氯醇、氯仿，能溶于氢氧化钠溶液，不溶于碳酸钠溶液，极微溶于水。
- 用途 分析试剂，检定二硫化碳和铊，重量测定铀，光度测定U+4，萃取银、铝、钡、铍、钙、镉、钴、铜、铁、镓、汞、锢、镧、镁、锰、镍、铅、钯、钪、钍、钛、锌、锆等。
- 用途 作为钙/锌羟酸盐稳定体系的共稳定剂，用来制造PVC矿泉水瓶
- 生产方法 由苄叉乙酰基苯为原料，经溴化、水解得到。
- 更新日期：2024/11/08
- 产品编号：A13450
- 产品名称：1,3-二苯基-1,3-丙二酮, 98+% 1,3-Diphenyl-1,3-propanedione, 98+%
- CAS编号：120-46-7
- 包装：25g
- 价格：409元
- 更新日期：2024/11/08
- 产品编号：A13450
- 产品名称：1,3-二苯基-1,3-丙二酮, 98+% 1,3-Diphenyl-1,3-propanedione, 98+%
- CAS编号：120-46-7
- 包装：100g
- 价格：1244元
- 公司名称：Acros Organics
- 联系电话：--
- 电子邮件：info@acros.com
- 国家：比利时
- 产品数：6772
- 优势度：81
