化合物 T11797
- CAS号:142523-14-6
- 英文名:1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE
- 中文名:化合物 T11797
- CBNumber:CB7169913
- 分子式:C32H52O16P2
- 分子量:754.69
- MOL File:142523-14-6.mol
- 沸点 :754.8±60.0 °C(Predicted)
- 密度 :1.232±0.06 g/cm3(Predicted)
- 储存条件 :Store at -80°C
- 酸度系数(pKa) :9.55±0.15(Predicted)
化合物 T11797性质、用途与生产工艺
- 生物活性 L-690488 是一种 L-690330 的前药,也是一种选择性的肌醇单磷酸酶 (IMPase) 抑制剂。L-690488 比 L-690330 具有更有效的细胞穿透能力。
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靶点
Inositol monophosphatase (IMPase)
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体外研究
The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC 50 values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [ 3 H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC 50 values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.
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