化合物 T11797
化合物 T11797 性质
| 沸点 | 754.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -80°C |
| 酸度系数(pKa) | 9.55±0.15(Predicted) |
化合物 T11797 用途与合成方法
Inositol monophosphatase (IMPase)
The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC
50
values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [
3
H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC
50
values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.
