化合物 T11797

生物活性靶点体外研究

CAS号:142523-14-6
英文名:1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE
中文名:化合物 T11797
CBNumber:CB7169913
分子式:C32H52O16P2
分子量:754.69
MOL File:142523-14-6.mol

化合物 T11797化学性质

化合物 T11797性质、用途与生产工艺

生物活性 L-690488 是一种 L-690330 的前药，也是一种选择性的肌醇单磷酸酶 (IMPase) 抑制剂。L-690488 比 L-690330 具有更有效的细胞穿透能力。
靶点

Inositol monophosphatase (IMPase)
体外研究

The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC ₅₀ values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [ ³ H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC ₅₀ values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.

化合物 T11797上下游产品信息

上游原料

下游产品

化合物 T11797生产厂家