红斑红素
- CAS号:514-67-0
- 英文名:RUBROPUNCTATIN
- 中文名:红斑红素
- CBNumber:CB71267988
- 分子式:C21H22O5
- 分子量:354.4
- MOL File:514-67-0.mol
- 熔点 :156.5-157.0 °C (decomp)(Solv: ethyl ether (60-29-7))
- 沸点 :638.8±55.0 °C(Predicted)
- 密度 :1.23±0.1 g/cm3(Predicted)
- 形态 :Solid
- 颜色 :Yellow to orange
红斑红素性质、用途与生产工艺
- 生物活性 Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎，免疫抑制和抗氧化作用，还具有抗肿瘤活性。
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体外研究
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.Cell Viability Assay
Cell Line: BGC-823 and GES-1cells Concentration: 1.5, 3, 6, 12, 15, 18, 30 μM Incubation Time: 24 hours Result: Decreased the viability of BGC-823 cells with an IC 50 of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.Cell Cycle Analysis
Cell Line: BGC-823 cells Concentration: 0, 5, 10, 30 μM Incubation Time: 0, 6, 12, 24 hours Result: Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
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体内研究
Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.
Rubropunctamine inhibits 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID 50 of 0.11 mg/ear.Animal Model: Male nude mice (5 weeks) are inoculated with BGC-823 cells Dosage: 8, 32 mg/kg Administration: I.v. five times (day 1st, 4th, 7th, 10th, and 13th) Result: Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.
- 公司名称：CLEARSYNTH LABS LTD.
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- 国家：印度
- 产品数：6257
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