泮托拉唑钠水合物
- CAS号:164579-32-2
- 英文名:PantoprazoleSodiumSesquihydrate
- 中文名:泮托拉唑钠水合物
- CBNumber:CB71075156
- 分子式:C16H18F2N3NaO5S
- 分子量:425.38
- MOL File:164579-32-2.mol
- 储存条件 :4°C, protect from light
- 溶解度 :Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.
- 形态 :Solid
- 颜色 :White to off-white
泮托拉唑钠水合物性质、用途与生产工艺
- 生物活性 Pantoprazole sodium hydrate (BY1023 sodium hydrate) 是一种具有口服活性的，有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole sodium hydrate 是一种取代的苯并咪唑，是一种有效的 H+/K+-ATPase 抑制剂，IC50 为 6.8 μM。Pantoprazo sodium hydrate 可以改善 pH 值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazo sodium hydrate 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。
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体外研究
Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.
Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H + -ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium -
体内研究
Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.
Animal Model: Mice bearing MCF-7 or A431 xenografts Dosage: 200 mg/kg Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.) Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.
Significantly increased tumor growth delay with a single dose with Doxorubicin.
There is no effect on growth delay alone.
- 更新日期：2024/11/08
- 产品编号：HY-17507B
- 产品名称：Pantoprazole sodium hydrate
- CAS编号：
- 包装：50 mg
- 价格：230元
- 更新日期：2024/11/08
- 产品编号：HY-17507B
- 产品名称：泮托拉唑钠水合物 Pantoprazole sodium hydrate
- CAS编号：164579-32-2
- 包装：100mg
- 价格：350元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
- 公司名称：Glentham Life Sciences
- 联系电话：--
- 电子邮件：info@glenthamls.com
- 国家：英国
- 产品数：1429
- 优势度：0
