莰菲醇-3-O-芸香糖苷

生物活性靶点体外研究体内研究莰菲醇-3-O-芸香糖苷试剂级价格

莰菲醇-3-O-芸香糖苷

CAS号:17650-84-9
英文名:KAEMPFEROL-3-O-RUTINOSIDE
中文名:莰菲醇-3-O-芸香糖苷
CBNumber:CB6690629
分子式:C27H30O15
分子量:594.52
MOL File:17650-84-9.mol

莰菲醇-3-O-芸香糖苷化学性质

熔点 :200°C (dec.)
沸点 :941.7±65.0 °C(Predicted)
密度 :1.76
储存条件 :Inert atmosphere,Store in freezer, under -20°C
溶解度 :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
形态 :Solid
酸度系数(pKa) :6.20±0.40(Predicted)
颜色 :Off-White to Yellow
稳定性 :Hygroscopic

安全信息

危险品标志 :Xn
危险类别码 :22
安全说明 :22-45-24/25
WGK Germany :3
海关编码 :29389090

莰菲醇-3-O-芸香糖苷性质、用途与生产工艺

生物活性 Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside) 是从 Carthamus tinctorius 中提取的黄酮，可改变受伤神经元的形状和结构，减少凋亡细胞，下调 p-JAK2、p-STAT3、caspase-3 和 Bax 的表达，并降低Bax免疫反应性，并增加 Bcl-2 蛋白表达和免疫反应性。
靶点
Target Value
p-JAK2
()
p-STAT3
()
caspase-3
()
Bax
()
Bcl-2
()
体外研究

For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions.
体内研究

At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits.
化学性质浅黄色针状结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于槐米，红花。
用途山奈酚-3-O-芸香糖苷具有降血脂，活血化瘀的作用。
用途用于含量测定/鉴定/药理实验等。
药理药效:降血脂、善痴呆症状和记忆保护