腺苷5'-二磷酸核糖钠
- CAS号:68414-18-6
- 英文名:Adenosine 5'-diphosphoribose sodium salt
- 中文名:腺苷5'-二磷酸核糖钠
- CBNumber:CB6667689
- 分子式:C15H22N5NaO14P2
- 分子量:581.3
- MOL File:68414-18-6.mol
- 储存条件 :-20°C
- 形态 :Solid
- 颜色 :White to light yellow
- 水溶解性 :Water : 125 mg/mL (215.04 mM)
- InChIKey :MBPRZUBFEMLFGQ-UUIVKEFHSA-M
- SMILES :O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|
腺苷5'-二磷酸核糖钠性质、用途与生产工艺
- 生物活性 Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物，也是一种最有效和最主要的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂，还可以增强自噬 (autophagy)。
-
靶点
TRPM2 channel
Autophagy -
体外研究
In mouse embryonic fibroblasts (MEFs), H 2 O 2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca 2+ elevation through extracellular Ca 2+ influx and (or) lysosomal Ca 2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca 2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
- 更新日期：2024/11/08
- 产品编号：HY-100973A
- 产品名称：Adenosine 5′-diphosphoribose sodium
- CAS编号：
- 包装：5 mg
- 价格：750元
- 更新日期：2024/11/08
- 产品编号：HY-100973A
- 产品名称：腺苷5'-二磷酸核糖钠 Adenosine 5′-diphosphoribose sodium
- CAS编号：68414-18-6
- 包装：10mg
- 价格：1050元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
