9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液

9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液化学性质

沸点 :519.7±30.0 °C(Predicted)
密度 :1.092±0.06 g/cm3(Predicted)
闪点 :-10 °C
储存条件 :-20°C
溶解度 :≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
酸度系数(pKa) :4.76±0.10(Predicted)
形态 :solution
颜色 :Colorless to light yellow
BRN :4267334

安全信息

9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液性质、用途与生产工艺

用途
U-46619是一种PGH2类似物，可以用作血栓烷A2（TP）受体激动剂，影响人类血管平滑肌的促有丝分裂生长。U 46619是稳定的血栓烷A2模拟物，是H2内过氧化物前列腺素的类似物，用作血管收缩剂和血栓烷受体激动剂。
生物活性 U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的血栓素 A2 (TXA2) 的类似物，也是一种有效的 TXA2 激动剂。
靶点

TXA2
体外研究

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC ₅₀ s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.
U-46619 (10 nM-10 μM) increases internal Ca ²⁺ concentration ([Ca ²⁺ ]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.

体内研究

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).

Animal Model:	12-15 weeks-old male and female SHR
Dosage:	5 μg/kg
Administration:	Intravenous injection
Result:	Induceed a significant increase of MABP after 1 min in male SHR.

9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液上下游产品信息

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