ChemicalBook CAS数据库列表 盐酸石蒜碱
盐酸石蒜碱
- CAS号:2188-68-3
- 英文名:Lycorine hydrochloride
- 中文名:盐酸石蒜碱
- CBNumber:CB6415905
- 分子式:C16H17NO4
- 分子量:287.31
- MOL File:2188-68-3.mol
盐酸石蒜碱化学性质
- 熔点 :206 °C
- 储存条件 :Keep in dark place,Inert atmosphere,2-8°C
- 溶解度 :Soluble in water (15 mg/ml)
- 形态 :powder
- 颜色 :White to off-white
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
安全信息
盐酸石蒜碱性质、用途与生产工艺
- 生物活性 Lycorine hydrochloride 是石蒜的主要活性成分，也是黑色素瘤血管生成抑制剂，具有抗肿瘤活性。Lycorine hydrochloride 能有效抑制 Hey1B 细胞的有丝分裂增殖 (IC50 为 1.2 μM)。
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靶点
IC50: 1.2 μM (Hey1B cells )
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体外研究
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.RT-PCR
Cell Line: C8161 cells Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time: 48 hours Result: Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells. Western Blot Analysis
Cell Line: C8161 cells Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time: 48 hours Result: Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion. -
体内研究
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Animal Model: 6- to 8-week-old BALB/C nude mice Dosage: 0 μg, 7.5 μg, 15 μg Administration: Subcutaneous injection; for 14 days Result: Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. - 化学性质 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于石蒜鳞茎。
- 用途 一种选择性的PTC抑制剂。
- 用途 肽转移酶中心（peptidyl transferase center ，PTC）的选择性抑制剂。
盐酸石蒜碱上下游产品信息
上游原料
下游产品
盐酸石蒜碱 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW21886831
- 产品名称：盐酸石蒜碱 lycorine hydrochloride
- CAS编号：2188-68-3
- 包装：1G
- 价格：398元
- 更新日期：2024/11/08
- 产品编号：HY-N0289
- 产品名称：盐酸石蒜碱 Lycorine hydrochloride
- CAS编号：2188-68-3
- 包装：25mg
- 价格：500元
盐酸石蒜碱生产厂家
- 公司名称：Pharma Affiliates
- 联系电话：--
- 电子邮件：@pharmaffiliates.com
- 国家：印度
- 产品数：6754
- 优势度：58
- 公司名称：Pharmaffiliates Analytics and Synthetics P. Ltd
- 联系电话：--
- 电子邮件：mktg@pharmaffiliates.com
- 国家：印度
- 产品数：6739
- 优势度：58
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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