ChemicalBook CAS数据库列表 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
生物活性 靶点 体内研究
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 试剂级价格
- CAS号:79547-78-7
- 英文名:1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- 中文名:1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
- CBNumber:CB6411376
- 分子式:C26H30ClFN2O2
- 分子量:456.99
- MOL File:79547-78-7.mol
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride化学性质
- 储存条件 :2-8°C
- 溶解度 :DMSO: ~10 mg/mL, soluble
- 形态 :solid
- 颜色 :white
安全信息
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride性质、用途与生产工艺
- 生物活性 Levocabastine hydrochloride (R 50547) 是一种具有抗过敏活性的长效、高效、选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型2 (NTR2) 拮抗剂，对 mNTR2 的 Ki 值为 17 nM。
-
靶点
H 1 Receptor
NTR2
17 nM (Ki)
-
体内研究
Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan.
In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased.
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride上下游产品信息
上游原料
下游产品
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-14277A
- 产品名称：1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Levocabastine hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：1000元
- 更新日期：2024/11/08
- 产品编号：HY-14277A
- 产品名称：1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Levocabastine hydrochloride
- CAS编号：79547-78-7
- 包装：5mg
- 价格：2700元
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride生产厂家
- 公司名称：Janssen Pharmaceutica NV
- 联系电话：--
- 电子邮件：JGCC_EMEA@its.jnj.com
- 国家：比利时
- 产品数：22
- 优势度：58
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