MVPQJUFFTWWKBT-LBDWYMBGSA-N
- CAS号:210344-97-1
- 英文名:MVPQJUFFTWWKBT-LBDWYMBGSA-N
- 中文名:MVPQJUFFTWWKBT-LBDWYMBGSA-N
- CBNumber:CB63554494
- 分子式:C31H39FN4O9
- 分子量:630.66
- MOL File:210344-97-1.mol
- 沸点 :945.2±65.0 °C(Predicted)
- 密度 :1.261±0.06 g/cm3(Predicted)
- 酸度系数(pKa) :9.81±0.15(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
MVPQJUFFTWWKBT-LBDWYMBGSA-N性质、用途与生产工艺
- 生物活性 Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性的、不可逆的 caspase-1 特异性抑制剂。
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靶点
Target Value caspase-1
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体外研究
Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells. Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%. Z-YVAD-FMK (1-10 μM; 24 hours) shows inhibitory effect in various cells against TNFr- or anti-CD95-induced cell death, exhibits IC 50 values of 0.0015 μM (Murine hepatocytes), 0.027 μM (Murine hepatocytes), 4.8 μM (HepG2), 5.8 μM (HepG2), 1.6 μM (Hela) and 1.1 μM (Jurkat), respectively.
Cell Viability Assay
Cell Line: Caco-2 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited Caco-2 cells growth. Apoptosis Analysis
Cell Line: BEL-7402 and HepG2 cells Concentration: 20 μM Incubation Time: Pre 1 hour; 24 hours Result: Induced a caspase-dependent apoptosis in cells. -
体内研究
Z-VAD-FMK (intraperitoneal injection; 10mg/kg; pre- 30 minutes) significantly delayed preterm delivery at 18 hours, but after 36 hours treatment, non different exists between Z-VAD-FMK-pretreated and control groups.
Animal Model: Day 14.5 pregnant CD1 mice Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10mg/kg; pre-30 minutes Result: Prevented HK-GBS-induced preterm delivery.
- 更新日期：2024/11/08
- 产品编号：S8507
- 产品名称：MVPQJUFFTWWKBT-LBDWYMBGSA-N Z-YVAD-FMK
- CAS编号：210344-97-1
- 包装：5mg
- 价格：4370元
- 更新日期：2024/11/08
- 产品编号：S8507
- 产品名称：Z-YVAD-FMK
- CAS编号：210344-97-1
- 包装：10mM (1mL in DMSO)
- 价格：5135.13元
- 公司名称：BOC Sciences
- 联系电话：16314854226; +16314854226
- 电子邮件：inquiry@bocsci.com
- 国家：美国
- 产品数：19741
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52925
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
