生物活性 靶点 体外研究 体内研究 MVPQJUFFTWWKBT-LBDWYMBGSA-N 试剂级价格
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MVPQJUFFTWWKBT-LBDWYMBGSA-N

MVPQJUFFTWWKBT-LBDWYMBGSA-N,210344-97-1,结构式
MVPQJUFFTWWKBT-LBDWYMBGSA-N
  • CAS号:210344-97-1
  • 英文名:MVPQJUFFTWWKBT-LBDWYMBGSA-N
  • 中文名:MVPQJUFFTWWKBT-LBDWYMBGSA-N
  • CBNumber:CB63554494
  • 分子式:C31H39FN4O9
  • 分子量:630.66
  • MOL File:210344-97-1.mol
MVPQJUFFTWWKBT-LBDWYMBGSA-N化学性质
  • 沸点 :945.2±65.0 °C(Predicted)
  • 密度 :1.261±0.06 g/cm3(Predicted)
  • 酸度系数(pKa) :9.81±0.15(Predicted)
  • 形态 :Solid
  • 颜色 :White to off-white

MVPQJUFFTWWKBT-LBDWYMBGSA-N性质、用途与生产工艺

  • 生物活性 Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性的、不可逆的 caspase-1 特异性抑制剂。
  • 靶点
    TargetValue
    caspase-1
    ()
  • 体外研究

    Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells. Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%. Z-YVAD-FMK (1-10 μM; 24 hours) shows inhibitory effect in various cells against TNFr- or anti-CD95-induced cell death, exhibits IC 50 values of 0.0015 μM (Murine hepatocytes), 0.027 μM (Murine hepatocytes), 4.8 μM (HepG2), 5.8 μM (HepG2), 1.6 μM (Hela) and 1.1 μM (Jurkat), respectively.

    Cell Viability Assay

    Cell Line: Caco-2 cells
    Concentration: 0-100 μM
    Incubation Time: 24 hours
    Result: Inhibited Caco-2 cells growth.

    Apoptosis Analysis

    Cell Line: BEL-7402 and HepG2 cells
    Concentration: 20 μM
    Incubation Time: Pre 1 hour; 24 hours
    Result: Induced a caspase-dependent apoptosis in cells.
  • 体内研究

    Z-VAD-FMK (intraperitoneal injection; 10mg/kg; pre- 30 minutes) significantly delayed preterm delivery at 18 hours, but after 36 hours treatment, non different exists between Z-VAD-FMK-pretreated and control groups.

    Animal Model: Day 14.5 pregnant CD1 mice
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection; 10mg/kg; pre-30 minutes
    Result: Prevented HK-GBS-induced preterm delivery.
MVPQJUFFTWWKBT-LBDWYMBGSA-N上下游产品信息
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MVPQJUFFTWWKBT-LBDWYMBGSA-N 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:S8507
  • 产品名称:MVPQJUFFTWWKBT-LBDWYMBGSA-N Z-YVAD-FMK
  • CAS编号:210344-97-1
  • 包装:5mg
  • 价格:4370元
  • 更新日期:2024/11/08
  • 产品编号:S8507
  • 产品名称:Z-YVAD-FMK
  • CAS编号:210344-97-1
  • 包装:10mM (1mL in DMSO)
  • 价格:5135.13元
MVPQJUFFTWWKBT-LBDWYMBGSA-N生产厂家
  • 公司名称:BOC Sciences
  • 联系电话:16314854226; +16314854226
  • 电子邮件:inquiry@bocsci.com
  • 国家:美国
  • 产品数:19741
  • 优势度:58
  • 公司名称:ChemeGen 中国
  • 联系电话: 18818260767
  • 电子邮件:sales@chemegen.com
  • 国家:中国
  • 产品数:11218
  • 优势度:58
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