N-乙酰-2-苄基色胺

生物活性靶点体外研究体内研究 N-乙酰-2-苄基色胺试剂级价格

N-乙酰-2-苄基色胺

CAS号:117946-91-5
英文名:LUZINDOLE
中文名:N-乙酰-2-苄基色胺
CBNumber:CB6268781
分子式:C19H20N2O
分子量:292.37
MOL File:117946-91-5.mol

N-乙酰-2-苄基色胺化学性质

熔点 :44-46°C
沸点 :434.31°C (rough estimate)
密度 :1.1045 (rough estimate)
折射率 :1.6140 (estimate)
储存条件 :-20°C
溶解度 :DMSO: 5 mg/mL
形态 :White to off-white crystalline solid.
酸度系数(pKa) :16.36±0.46(Predicted)
颜色 :Off-White to Yellow
水溶解性 :Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.
稳定性 :Store at -20°C
CAS 数据库 :117946-91-5(CAS DataBase Reference)

安全信息

安全说明 :24/25
WGK Germany :3
RTECS号 :AC7765700
海关编码 :29339980

N-乙酰-2-苄基色胺性质、用途与生产工艺

生物活性 Luzindole (N-0774) 是一种选择性褪黑素受体 (melatonin receptor) 拮抗剂。Luzindole 优先靶向 MT2 (Mel1b)，对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。Luzindole 抑制实验性自身免疫性脑脊髓炎，并发挥抗抑郁样活性。
靶点

Ki :10.2 nM (human MT2), 158 nM (human MT1)
体外研究

Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line.

体内研究

Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis.
Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin.

Animal Model:	Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice
Dosage:	30 mg/kg
Administration:	i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting)
Result:	Effectively prevented experimental autoimmune encephalomyelitis.