11β-羟基雄甾-4-烯-3,17-二酮
- CAS号:382-44-5
- 英文名:11β-Hydroxyandrost-4-ene-3,17-dione
- 中文名:11β-羟基雄甾-4-烯-3,17-二酮
- CBNumber:CB6136789
- 分子式:C19H26O3
- 分子量:302.41
- MOL File:382-44-5.mol
- 熔点 :197-199℃
- 沸点 :475.3±45.0 °C(Predicted)
- 密度 :1.19±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 250 mg/mL (826.69 mM)
- 形态 :A crystalline solid
- 酸度系数(pKa) :14.49±0.60(Predicted)
- 颜色 :White to off-white
- WGK Germany :3
11β-羟基雄甾-4-烯-3,17-二酮性质、用途与生产工艺
- 生物活性 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。
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靶点
Human Endogenous Metabolite
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体外研究
In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
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体内研究
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.
- 更新日期：2024/11/08
- 产品编号：HY-114464
- 产品名称：4-雄烯-11β-醇-3,17-二酮 11-Beta-hydroxyandrostenedione
- CAS编号：382-44-5
- 包装：5mg
- 价格：400元
- 更新日期：2024/11/08
- 产品编号：HY-114464
- 产品名称：4-雄烯-11β-醇-3,17-二酮 11-Beta-hydroxyandrostenedione
- CAS编号：382-44-5
- 包装：10mM * 1mLin DMSO
- 价格：440元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
