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去氧鬼臼脂素

去氧鬼臼脂素,19186-35-7,结构式
去氧鬼臼脂素
  • CAS号:19186-35-7
  • 英文名:Desoxypodophyllotoxin
  • 中文名:去氧鬼臼脂素
  • CBNumber:CB61267789
  • 分子式:C22H22O7
  • 分子量:398.41
  • MOL File:19186-35-7.mol
去氧鬼臼脂素化学性质
  • 储存条件 :Store at 2-8°C
  • 溶解度 :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • 形态 :Powder
  • 沸点 :564.5±50.0 °C(Predicted)
  • 密度 :1.304±0.06 g/cm3(Predicted)
  • 熔点 :168 °C
  • 稳定性 :Hygroscopic

去氧鬼臼脂素性质、用途与生产工艺

  • 生物活性 Deoxypodophyllotoxin (DPT),鬼臼毒素的衍生物,是一种木酚素,从 Sinopodophullumhexandrum (小檗科)的根茎分离,具有强效抗有丝分裂和抗病毒特性。Deoxypodophyllotoxin 作为靶向微管的药物,不仅抗有丝分裂剂而且作为有效的血管生成抑制剂,在肿瘤学中具有重大影响。Deoxypodophyllotoxin 诱导细胞自噬 (autophagy) 和细胞凋亡 (apoptosis)。 Deoxypodophyllotoxin 引起 DRG 神经元细胞内 Ca2+ 浓度增加。
  • 体外研究

    Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity.

    Apoptosis Analysis

    Cell Line: SGC-7901 cells
    Concentration: 25, 50, 75 nM
    Incubation Time: 6, 12, 24, 48 hours
    Result: Induced apoptosis in SGC-7901 Cells.

    Cell Cycle Analysis

    Cell Line: SGC-7901 cells
    Concentration: 25, 50, 75 nM
    Incubation Time: 6, 12, 24, 48 hours
    Result: Induced G2/M cell cycle arrest in SGC-7901 Cells

    Western Blot Analysis

    Cell Line: SGC-7901 cells
    Concentration: 25, 50, 75 nM
    Incubation Time: 6, 12, 24, 48 hours
    Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins.
  • 体内研究

    Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively.

    Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells
    Dosage: 5, 10, and 20 mg/kg
    Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days
    Result: Inhibited the growth of gastric cancer tumors.
  • 化学性质  无色棱柱状结晶(无水乙醇),可溶于甲醇、乙醇、DMSO等有机溶剂,来源于桃儿七Sinopodophyllum hexandrum (Royle) Ying;八角莲Dysosma versipellis (Hance) M. Cheng ex Ying的根茎。
  • 用途  去氧鬼臼毒素具有抗肿瘤活性。
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去氧鬼臼脂素生产厂家
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:96815
  • 优势度:76
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