ChemicalBook CAS数据库列表 法贝司琼
法贝司琼
- CAS号:129300-27-2
- 英文名:Fabesetron
- 中文名:法贝司琼
- CBNumber:CB61178694
- 分子式:C18H19N3O
- 分子量:293.36
- MOL File:129300-27-2.mol
法贝司琼性质、用途与生产工艺
- 生物活性 Fabesetron (FK1052) 是具有口服活性的 5-HT3 和 5-HT4 受体的拮抗剂。Fabesetron (FK1052) 可用于癌症化疗引起的急性和迟发性呕吐的研究。
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靶点
5-HT 3 Receptor
5-HT 4 Receptor
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体内研究
Fabesetron (FK1052) (0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit.
FK1052 (100 µg/kg) completely prevents emesis induced by cisplatin (18 mg/kg, i.p.) in Suncus murinus .
Animal Model: Male Sprague-Dawley rats weighing 220 to 330 g and male ddy mice weighing 25 to 35 g were used. Dosage: 0.1 mg/kg. Administration: P.O. Result: Significantly caused delay and its degree of inhibition was 33.8 ± 4.8% by 0.1 mg/kg p.o.. Animal Model: Suncus murinus of either sex (>10-week-old; 30-70 g body weight). Dosage: 1, 10, and 100 µg/kg. Administration: Orally administered 30 min before the injection of cisplatin. Result: Inhibited cisplatininduced emesis in a dose-dependent manner, and no emesis was observed in three animals given the compound at 100 µg/kg.
法贝司琼上下游产品信息
上游原料
下游产品
法贝司琼生产厂家
- 公司名称:MedChemExpress
- 联系电话:--
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- 国家:美国
- 产品数:6398
- 优势度:58
- 公司名称:HONEST JOY HOLDINGS LIMITED
- 联系电话:--
- 电子邮件:sales@honestjoy.cn
- 国家:美国
- 产品数:6702
- 优势度:54