法贝司琼
中文名称:法贝司琼
英文名称:Fabesetron
CAS号:129300-27-2
分子式:C18H19N3O
分子量:293.36
EINECS号:
Mol文件:129300-27-2.mol
法贝司琼 用途与合成方法
Fabesetron (FK1052) 是具有口服活性的 5-HT3 和 5-HT4 受体的拮抗剂。Fabesetron (FK1052) 可用于癌症化疗引起的急性和迟发性呕吐的研究。
5-HT 3 Receptor
|
5-HT 4 Receptor
|
Fabesetron (FK1052) (0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit.
FK1052 (100 µg/kg) completely prevents emesis induced by cisplatin (18 mg/kg, i.p.) in
Suncus murinus
.
Animal Model: | Male Sprague-Dawley rats weighing 220 to 330 g and male ddy mice weighing 25 to 35 g were used. |
Dosage: | 0.1 mg/kg. |
Administration: | P.O. |
Result: | Significantly caused delay and its degree of inhibition was 33.8 ± 4.8% by 0.1 mg/kg p.o.. |
Animal Model: | Suncus murinus of either sex (>10-week-old; 30-70 g body weight). |
Dosage: | 1, 10, and 100 µg/kg. |
Administration: | Orally administered 30 min before the injection of cisplatin. |
Result: | Inhibited cisplatininduced emesis in a dose-dependent manner, and no emesis was observed in three animals given the compound at 100 µg/kg. |
法贝司琼供应商 更多
天津普西唐生物医药科技有限公司
联系电话:010-60605840
产品介绍:
中文名称:法贝司琼
英文名称:Fabesetron
CAS:129300-27-2
纯度:95%
包装信息:100mg
常州博嘉生物医药科技有限公司
联系电话: 2122619822
产品介绍:
英文名称:129300-27-2
CAS:129300-27-2
纯度:99% HPLC
包装信息:1G;5G;10G;100G;1KG;
备注:医药级
TargetMol中国(陶术生物)
联系电话: 15002134094
产品介绍:
中文名称:法贝司琼
英文名称:Fabesetron
CAS:129300-27-2
纯度:详情请点击官网
包装信息:1 mg
备注:试剂级