钒酸钠

理化性质应用生物活性靶点体外研究钒酸钠试剂级价格

钒酸钠

CAS号:13721-39-6
英文名:Sodium orthovanadate
中文名:钒酸钠
CBNumber:CB6111122
分子式:Na3VO4
分子量:183.91
MOL File:13721-39-6.mol

钒酸钠化学性质

熔点 :850-866 °C(lit.)
储存条件 :Sealed in dry,Room Temperature
溶解度 :H₂O: soluble
形态 :Solid
颜色 :off-white
水溶解性 :soluble
暴露限值 :NIOSH: Ceiling 0.05 mg/m3
稳定性 :Stable. Incompatible with strong oxidizing agents.
CAS 数据库 :13721-39-6(CAS DataBase Reference)
EPA化学物质信息 :Sodium vanadium oxide (Na3VO4) (13721-39-6)

安全信息

危险品标志 :Xn
危险类别码 :20/21/22
安全说明 :22-36
危险品运输编号 :UN3285
WGK Germany :3
RTECS号 :YW1120000
TSCA :Yes
危险等级 :6.1
包装类别 :III
海关编码 :28419030

钒酸钠 MSDS

Sodium orthovanadate

钒酸钠性质、用途与生产工艺

理化性质钒酸钠。化学式Na3VO4。分子量183.94。无色六方系柱状晶体。熔点850～866℃。其十水合物为白色立方系或六方系晶体，其十六水合物为白色针状晶体,熔点866℃。能溶于水，不溶于乙醇。
应用钒酸钠属于无机盐化合物，主要用作催化剂、油漆催干剂、媒染剂、缓蚀剂等，也用于制备其他钒盐。
生物活性 Sodium orthovanadate是蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP酶的抑制剂，最有可能充当磷酸盐类似物。
靶点

PPTPase.
体外研究

In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO4 ^2- or H2VO ^4- ) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia.
用途几种磷酸酶和磷酸激酶的抑制剂
生产方法由五氧化二钒与氧化钠或碳酸钠共热反应而制得钒酸钠。