苯丝氨酸

生物活性靶点体外研究体内研究苯丝氨酸试剂级价格

苯丝氨酸

CAS号:101246-66-6
英文名:PHENSERINE
中文名:苯丝氨酸
CBNumber:CB5731231
分子式:C20H23N3O2
分子量:337.42
MOL File:101246-66-6.mol

苯丝氨酸化学性质

熔点 :151-152 °C
沸点 :468.7±45.0 °C(Predicted)
密度 :1.228±0.06 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :H2O: <2mg/mL
形态 :solid
酸度系数(pKa) :13.05±0.70(Predicted)
颜色 :off-white

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26
WGK Germany :3
RTECS号 :UY8586000

苯丝氨酸性质、用途与生产工艺

生物活性 Phenserine ((-)-Eseroline phenylcarbamate) 是 Physostigmine 的衍生物，是一种有效的，非竞争性，长效和选择性的 AChE 抑制剂。Phenserine 可减少 β-淀粉样蛋白前体蛋白 (APP) 和 β-淀粉样肽 (Aβ) 的形成。Phenserine 可改善认知能力并减轻阿尔茨海默氏病的进展。
靶点

AChE; β-amyloid precursor protein; β-amyloid peptide

体外研究

Phenserine (1-25 μM; 48 hours; CHO APP _751SW cells) treatment CHO APP _751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%.

Western Blot Analysis

Cell Line:	CHO APP _751SW cells
Concentration:	1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM
Incubation Time:	48 hours
Result:	8.6% reduction in cells treated with 10 μM, while 25 μM concentration reduces APP level by 51.4%.

体内研究

Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task.

Animal Model:	Male Fischer-344 rats (5 months old) induced by scopolamine
Dosage:	1 mg/kg, 2 mg/kg, 4 mg/kg
Administration:	Intraperitoneal injection; for 4 days
Result:	Improved morris water maze performance of scopolamine-treated rats..