ChemicalBook CAS数据库列表 己酮可可碱
己酮可可碱
- CAS号:6493-05-6
- 英文名:Pentoxifylline
- 中文名:己酮可可碱
- CBNumber:CB5721652
- 分子式:C13H18N4O3
- 分子量:278.31
- MOL File:6493-05-6.mol
己酮可可碱化学性质
- 熔点 :98-100°C
- 沸点 :421.13°C (rough estimate)
- 密度 :1.1713 (rough estimate)
- 折射率 :1.6000 (estimate)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :H2O: ≥43 mg/mL
- 形态 :solid
- 酸度系数(pKa) :0.50±0.70(Predicted)
- 颜色 :white
- 最大波长(λmax) :276nm(lit.)
- Merck :14,7136
- CAS 数据库 :6493-05-6(CAS DataBase Reference)
- NIST化学物质信息 :Pentoxifylline(6493-05-6)
- EPA化学物质信息 :1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)- (6493-05-6)
安全信息
己酮可可碱 化学药品说明书
己酮可可碱肠溶片|药典2005版
己酮可可碱|药典2005版
己酮可可碱性质、用途与生产工艺
- 生物活性 Pentoxifylline (BL-191) 是一种血液流变学改善剂。Pentoxifylline 是一种具有口服活性的，非选择性的磷酸二酯酶 (PDE) 抑制剂，具有免疫调节、抗炎、血液流变学改善、抗纤溶和抗增殖作用。Pentoxifylline 可用于研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
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靶点
PDE
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体外研究
Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.
Pentoxifylline results in high LC3-II/LC3-ratio.
Cell Autophagy Assay
Cell Line: MDA-MB-231 cells Concentration: 0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM Incubation Time: 24 hours, 48 hours Result: Inhibited cell proliferation in a dose-dependent manner. Apoptosis Analysis
Cell Line: MDA-MB-231 cells Concentration: 0.5 mM Incubation Time: 12 hours, 24 hours, 36 hours Result: Induced apoptosis. Apoptosis Analysis
Cell Line: MDA-MB-231 cells Concentration: 0.5 mM Incubation Time: 24 hours, 48 hours Result: Induced approximately 20-28% of cell autophagy. Cell Cycle Analysis
Cell Line: MDA-MB-231 cells Concentration: 0.5 mM Incubation Time: 24 hours, 48 hours Result: Induced G0/G1 phase arrest. Western Blot Analysis
Cell Line: MDA-MB-231 cells Concentration: 0.5 mM Incubation Time: 24 hours, 48 hours Result: Induced high LC3-II/LC3-ratio. -
体内研究
Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and could reduce cognitive impairment.
Animal Model: Adult male Wistar rats 12-13-weeks-old (250-300 g) Dosage: 200 mg/kg Administration: Intraperitoneal injection, at 1hr before and 3 hr after ischemia Result: Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups. - 化学性质 白色针状结晶。熔点105℃。易溶于水、苯、乙醇、氯仿，微溶于乙醇。无臭，味苦。
- 用途 该品为血管扩张药，能改善脑和四肢的血液循环。小鼠口服LD50为1385mg/kg。
- 生产方法 由1，3-溴氯丙烷与乙酰乙酸乙酯在80℃左右环合得到2-甲基-3-乙氧羰基-5，6-二氢吡喃，再将其开环、溴化生成1-溴-5-已酮，然后与可可碱钠盐缩合制成已酮可可碱。
己酮可可碱上下游产品信息
上游原料
下游产品
己酮可可碱 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-B0715
- 产品名称：己酮可可碱 Pentoxifylline
- CAS编号：6493-05-6
- 包装：500mg
- 价格：400元
- 更新日期：2024/11/08
- 产品编号：HY-B0715
- 产品名称：己酮可可碱 Pentoxifylline
- CAS编号：6493-05-6
- 包装：10mM * 1mLin DMSO
- 价格：500元
己酮可可碱生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
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