N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
- CAS号:1287585-40-3
- 英文名:N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
- 中文名:N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
- CBNumber:CB56226324
- 分子式:C20H31N5O5S
- 分子量:453.56
- MOL File:1287585-40-3.mol
- 沸点 :902.5±65.0 °C(Predicted)
- 密度 :1.273±0.06 g/cm3(Predicted)
- 储存条件 :-20°C, protect from light
- 酸度系数(pKa) :9.18±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE性质、用途与生产工艺
- 生物活性 N-Acetyl lysyltyrosylcysteine amide 是一种有效的，可逆的，特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。
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体内研究
N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.Animal Model: 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode) Dosage: 10 mg/kg Administration: I.p.; daily for 3-7 days Result: Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32165
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
