生物活性 体内研究
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
ChemicalBook  CAS数据库列表  N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE

N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE

生物活性 体内研究
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE,1287585-40-3,结构式
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
  • CAS号:1287585-40-3
  • 英文名:N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
  • 中文名:N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
  • CBNumber:CB56226324
  • 分子式:C20H31N5O5S
  • 分子量:453.56
  • MOL File:1287585-40-3.mol
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE化学性质
  • 沸点 :902.5±65.0 °C(Predicted)
  • 密度 :1.273±0.06 g/cm3(Predicted)
  • 储存条件 :-20°C, protect from light
  • 酸度系数(pKa) :9.18±0.10(Predicted)
  • 形态 :Solid
  • 颜色 :White to off-white

N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE性质、用途与生产工艺

  • 生物活性 N-Acetyl lysyltyrosylcysteine amide 是一种有效的，可逆的，特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。
  • 体内研究

    N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
    N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
    N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.

    Animal Model: 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
    Dosage: 10 mg/kg
    Administration: I.p.; daily for 3-7 days
    Result: Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE上下游产品信息
上游原料
下游产品
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE生产厂家
  • 公司名称：上海超岚化工科技中心
  • 联系电话：021-QQ：65489617 15618227136
  • 电子邮件：Sales@ATKchemical.com
  • 国家：中国
  • 产品数：7268
  • 优势度：58
  • 公司名称：成都云希化工有限公司
  • 联系电话：+86-17380623303 +86-17380623303
  • 电子邮件：Caroline@youngshechem.com
  • 国家：中国
  • 产品数：4837
  • 优势度：58
  • 公司名称：广州优南科技有限公司
  • 联系电话：020-82000279 18988968278
  • 电子邮件：sales@ubiochem.com
  • 国家：中国
  • 产品数：4297
  • 优势度：58
关注Chemicalbook 进入官方账号