867164-40-7
- CAS号:867164-40-7
- 英文名:TRC051384
- 中文名:867164-40-7
- CBNumber:CB53171704
- 分子式:C25H31N5O4
- 分子量:465.54
- MOL File:867164-40-7.mol
- 沸点 :685.7±55.0 °C(Predicted)
- 密度 :1.260±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
- 形态 :solid
- 酸度系数(pKa) :13.47±0.46(Predicted)
- 颜色 :Yellow
867164-40-7性质、用途与生产工艺
- 生物活性 TRC051384是热休克蛋白70 (HSP70) 诱导剂。
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靶点
HSP70
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体外研究
TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
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体内研究
Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
- 更新日期:2024/11/08
- 产品编号:HY-101712
- 产品名称:TRC051384
- CAS编号:
- 包装:1 mg
- 价格:400元
- 更新日期:2024/11/08
- 产品编号:HY-101712
- 产品名称:867164-40-7 TRC051384
- CAS编号:867164-40-7
- 包装:5mg
- 价格:900元
- 公司名称:TOCRIS-US
- 联系电话:--
- 电子邮件:customerservice@tocris.co.uk
- 国家:英国
- 产品数:5726
- 优势度:77