867164-40-7
867164-40-7 性质
| 沸点 | 685.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.260±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 不溶于乙醇；不溶于水； DMSO 中≥109 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.47±0.46(Predicted) |
| 颜色 | 粘黄色 |
| SMILES | O=C(C1=CC=C(NC(NCCN2CCOCC2)=O)C=C1)/C=C/C3=CC=CC(N4CCOCC4)=N3 |
867164-40-7 用途与合成方法
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HSP70
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TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
867164-40-7 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-101712 | 867164-40-7 | 1 mg | 400 | |
| 2026-09-15 | HY-101712 | 867164-40-7 | 867164-40-7 | 5mg | 900 |
