生物活性 靶点 体外研究 体内研究 (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA 试剂级价格
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ChemicalBook  CAS数据库列表  (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA

(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA

生物活性 靶点 体外研究 体内研究 (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA 试剂级价格
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA,145084-28-2,结构式
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA
  • CAS号:145084-28-2
  • 英文名:(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA
  • 中文名:(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA
  • CBNumber:CB5302859
  • 分子式:C32H28N4O3
  • 分子量:516.59
  • MOL File:145084-28-2.mol
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA化学性质
  • 熔点 :187-190 °C
  • 沸点 :735.4±60.0 °C(Predicted)
  • 密度 :1.23±0.1 g/cm3(Predicted)
  • 储存条件 :Store at RT
  • 溶解度 :DMSO: soluble5mg/mL (clear solution)
  • 形态 :powder
  • 酸度系数(pKa) :11.61±0.40(Predicted)
  • 颜色 :white to beige
  • 旋光性 (optical activity) :[α]/D -128 to -140 (c = 1, DCM)
安全信息
  • 危险品标志 :T
  • 危险类别码 :25
  • 安全说明 :45
  • 危险品运输编号 :UN 2811 6.1 / PGIII
  • WGK Germany :3

(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA性质、用途与生产工艺

  • 生物活性 YM022 是一种高效，选择性和口服活性胃泌素/胆囊收缩素(CCK)-B 受体 (CCK-BR) 拮抗剂。 YM022 显示CCK-B 和 CCK-A 受体的 Ki 值分别为 68 pM 和 63 nM。 YM022 在体内可以抑制胃泌素诱导的胃酸分泌和组氨酸脱羧酶的活化。
  • 靶点

    CCR1

    68 pM (Ki)

    CCR2

    63 nM (Ki)

  • 体外研究

    YM022 inhibits binding to canine pancreas CCK-A receptor in a dose-dependent manner, with an IC 50 value for [ 3 H]devazepide binding of 136 nM.
    YM022 inhibits the binding of [ 125 I]CCK-8 to canine cloned gastrin/CCK-B receptor in a dose-dependent manner, with an IC 50 value for [ 125 I]CCK-8 binding of 0.73 nM.
    Selectivity [ratio of (IC 50 for gastrin/CCK-B receptor)/(IC 50 for CCK-A receptor)] of YM022 is 186.

  • 体内研究

    YM022 (intravenous injection; 0.01-1 μM/kg) dose-dependently inhibits pentagastrin- and peptone meal-induced acid secretion with ED 50 values of 0.0261 and 0.0654 μmol/kg, respectively, without affecting histamine- or methacholine-induced acid secretion.
    YM022 (subcutaneous injection; 300 μmol/kg; single dose) lowers the oxyntic mucosal HDC activity and raises the serum gastrin concentration in a dose-dependent manner (measured 24 h after dosage). Maximum enzyme inhibition is achieved at a dose of 300 μmol/kg  for YM022 and the inhibition of HDC lasts for 4 weeks. At sacrifice, drug residues can be seen at the injection site for as long as 4 (YM022) weeks after injection in rat.
    YM022 is suspended in 2% Methocel for oral ingestion and in PEG300 for subcutaneous injection.

    Animal Model: Rat
    Dosage: 300 μmol/kg
    Administration: Subcutaneous injection; 300 μmol/kg; single dose
    Result: Suppressed the ECL cell activity for at least 4 as manifested in greatly reduced HDC activity, greatly elevated serum gastrin level.
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA上下游产品信息
上游原料
下游产品
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-103355
  • 产品名称：YM022
  • CAS编号：
  • 包装：1 mg
  • 价格：1590元
  • 更新日期：2024/11/08
  • 产品编号：HY-103355
  • 产品名称：(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA YM022
  • CAS编号：145084-28-2
  • 包装：5mg
  • 价格：3500元
(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA生产厂家
  • 公司名称：Service Chemical Inc.
  • 联系电话：--
  • 电子邮件：sales@chemos-group.com
  • 国家：德国
  • 产品数：6350
  • 优势度：71
  • 公司名称：BIOTREND Chemicals AG
  • 联系电话：--
  • 电子邮件：info@biotrend.ch
  • 国家：德国
  • 产品数：1250
  • 优势度：62
145084-28-2, (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA相关搜索:
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